Unifiram

Description

Overview of Unifiram 

Unifiram (DM232) is a synthetic experimental chemical that shares structural similarities with piracetam. Its pharmacological profile and mechanistic effects on neuronal signaling pathways have been investigated. As one of several racetam-like compounds, Unifiram is studied in laboratories using regulated in vitro and ex vivo models, with an emphasis on how it interacts with the cholinergic and glutamatergic systems. It is important to note that this chemical is supplied for research purposes only.

Chemical and Molecular Properties 

Unifiram
PubChem CID	9861054
Molecular Formula	C13H15FN2O3S
Molecular Weight	298.34 g/mol
Synonyms	UNII-N4024LN29G DTXSID00432024
IUPAC	2-(4-fluorophenyl)sulfonyl-1,3,4,7,8,8a-hexahydropyrrolo[1,2-a]pyrazin-6-one
CAS	272786-64-8
Labeling	Research Use Only (RUO), not for human or animal consumption.
Chemical Structure Depiction
Purity	≥98%
Classification	Research Use Only (RUO)
Storage Temperature	2–8 °C recommended; protect from light
Solubility	Soluble in DMSO and research‑grade organic solvents
Safety	Handle with gloves, a lab coat, eye protection; use a fume hood if dust/aerosol is possible

Various Mechanisms of Unifiram

Modulation of AMPA-Dependent Synaptic Signaling

Preclinical studies using hippocampal slice preparations show that Unifiram can increase field excitatory postsynaptic potential (fEPSP) amplitudes, implicating AMPA-type glutamate receptor pathways in its mechanistic profile. These effects are examined in laboratory models to understand how excitatory synaptic transmission can be indirectly enhanced

Lack of Direct Classic Receptor Activation

Binding studies in controlled experimental models demonstrate that Unifiram (DM232) does not interact significantly with common neurotransmitter receptors or ion channels at tested in vitro concentrations. These findings indicate that the observed modulation of synaptic activity occurs through indirect mechanisms rather than classic receptor agonism or antagonism

Cholinergic Release Modulation 

In experimental cortical tissue models, Unifiram has been reported to enhance acetylcholine release, demonstrating modulation of cholinergic pathways in neural circuits. These effects are studied in controlled preclinical models to explore neurotransmitter dynamics without direct receptor binding

Unifiram Research Applications 

Unifiram is principally utilized in research contexts to study molecular and cellular mechanisms associated with excitatory neurotransmission and synaptic plasticity. Preclinical and in vitro research applications include:

• Exploration of glutamatergic synaptic signaling pathways using electrophysiological recordings.
• Investigation of acetylcholine release dynamics and cholinergic modulation in isolated neural tissues.
• Characterization of indirect synaptic modulators that affect fEPSP amplitude in hippocampal slice assays.
• Structure‑activity relationship research for novel analogues of DM232 and related investigational ligands.

Research usage focuses on mechanistic understanding of neural signaling pathways in controlled experimental models rather than effects in clinical populations. Unifiram is currently under investigation and has not been approved by the FDA. It is exclusively granted for the purpose of research only. 

Why Choose Purerawz for Unifiram?

Buy Unifiram for laboratory research use from our online shop. At Purerawz, we provide high-quality reference materials. Each research compound comes with a Certificate of Analysis for verification of purity and concentration.

Note:

Unifiram is an investigational compound currently undergoing clinical evaluation and has not been established as safe or effective for any therapeutic use

Disclaimer

This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By ordering, you agree to our Terms and Conditions. If you are not 100% satisfied with the product you received, please contact us at support@staging.purerawz.co

ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human use

Reference Links

Galeotti N., Ghelardini C., Pittaluga A., et al. AMPA‑receptor activation is involved in the antiamnesic effect of DM232 (unifiram) and DM235 (sunifiram). Naunyn Schmiedebergs Archives of Pharmacology. 368(6):538–545. https://pubmed.ncbi.nlm.nih.gov/14600801/

Romanelli M. N., Galeotti N., Ghelardini C., et al. Pharmacological Characterization of DM232 (Unifiram) and DM235 (Sunifiram), New Potent Cognition Enhancers. CNS Drug Reviews, 12(1):39–52. https://pubmed.ncbi.nlm.nih.gov/16834757/

Scapecchi S., Martini E., Manetti D., et al. Structure–activity relationship studies on unifiram (DM232) and sunifiram (DM235), two novel and potent cognition enhancing drugs. Bioorganic & Medicinal Chemistry. 12(1):71–85. https://pubmed.ncbi.nlm.nih.gov/14697772/

PubChem Compound Summary for Unifiram (CAS 272786–64–8). National Center for Biotechnology Information, U.S. National Library of Medicine. https://pubchem.ncbi.nlm.nih.gov/compound/Unifiram