Picamilon Sodium (Nicotinoyl-GABA)

Description

Overview of Picamilon

Picamilon is a synthetic molecular conjugate. It contains Y-aminobutyric acid (GABA) and niacin (vitamin B3). This chemical design is intended to alter pharmacokinetic properties relative to individual components. Picamilon is studied in mechanistic research contexts to explore how chemical linkage influences:

• compound distribution
• receptor interactions
• and molecular signaling pathways.

The compound has been used as a reference material in laboratory settings to probe neuronal receptor interactions and transporter dynamics.

Chemical and Molecular Properties

Property	Description
Compound Name	N-nicotinoyl-Y-aminobutyric acid (Picamilon)
Synonyms	Nicotinoyl-GABA; Pikamilon; Pikatropin
Molecular Formula	C10H12N2O3
Molecular Weight	~208.21 g/mol
CAS Number	34562-97-5
Structural Class	GABA derivative/niacin conjugate
Chemical Nature	Synthetic small molecule
Research Classification	Neuronal signaling and transport investigational compound

Working Mechanism of Picamilon

Molecular Conjugation and Transport

Picamilon is structurally composed of the inhibitory neurotransmitter analogue Y-aminobutyric acid (GABA) chemically linked to niacin. This design alters lipophilicity relative to GABA alone. It has been investigated in preclinical research for its ability to influence membrane permeability in controlled experimental systems.

Interaction with GABA-Related Targets

GABA itself exhibits specific interactions with GABA receptor subtypes. Recent assays also indicate that Picamilon, despite structural similarity, does not exhibit high affinity across a panel of 50 biological targets, including major ion channels, transporters, and receptor proteins at typical in vitro screening concentrations. This suggests that the mechanisms of action in mechanistic studies may involve indirect modulation or metabolic transformation in experimental preparations rather than direct receptor agonism.

Metabolic Transformation in Experimental Models

In controlled research environments, Picamilon has been observed to be hydrolyzed into its constituent moieties - GABA and niacin - under specific conditions. These component molecules can then be evaluated independently for receptor interaction profiles and signaling effects in mechanistic assays.

Picamilon Research Applications (Laboratory Use Only)

• In vitro studies of inhibitor and transporter activity related to GABA analogues
• Experimental evaluation of compound distribution and membrane permeability
• Biochemical assays of metabolic breakdown products (GABA and niacin)
• Mechanistic receptor binding profiling using high-throughput screening methods

These applications are strictly confined to laboratory research and analytical investigations.

Why Choose Purerawz for Picamilon?

Buy Picamilon (N-nicotinoyl-Y-aminobutyric acid) for laboratory research use from our online shop. At Purerawz, we provide high-quality reference materials. Each research compound comes with a Certificate of Analysis for verification of purity and concentration.

Note: Picamilon is an investigational compound currently undergoing scientific evaluation and has not been established as safe or effective for any therapeutic use.

Disclaimer

This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By ordering, you agree to our Terms and Conditions. If you are not 100% satisfied with the product you received, please contact us at support@staging.purerawz.co

ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human use.

Reference Links

Santillo, M. F., & Sprando, R. L. (2023). Picamilon, a Y-aminobutyric acid analogue, is inactive against 50 biological targets. Basic & Clinical Pharmacology & Toxicology, 132(4), 355-358. https://doi.org/10.1111/bcpt.13836/

Picamilon (N-nicotinoyl-Y-aminobutyric acid) - pharmacology and metabolism overview. Wikipedia. https://en.wikipedia.org/wiki/Picamilon