IDRA-21

Description

Overview of IDRA-21

IDRA-21 is a benzothiadiazine derivative research compound classified as an ampakine. It acts as a positive allosteric modulator of AMPA-type glutamate receptors. This influences receptor conformation and excitatory synaptic signaling at the molecular level.

Chemical and Molecular Properties

IDRA-21
PubChem CID	3688
Molecular Formula	C8H9ClN2O2S
Molecular Weight	232.69 g/mol
Synonyms	22503-72-6; IDRA-21; idra 21; 689UW7PT68; IDRA21
IUPAC	7-chloro-3-methyl-3,4-dihydro-2H-1λ6,2,4-benzothiadiazine 1,1-dioxide
CAS	22503-72-6
Labeling	Research Use Only (RUO), not for human or animal consumption.
Chemical Structure Depiction
Purity	≥98%
Classification	Benzothiadiazine derivative; research compound; AMPA receptor positive allosteric modulator
Storage Temperature	Lyophilized: –20 °C or colder
Safety	Handle with gloves, a lab coat, eye protection; use a fume hood if dust/aerosol is possible

IDRA-21 Mechanism of Action

Positive Allosteric Modulation of AMPA Receptors

IDRA–21 acts as a positive allosteric modulator of AMPA-type glutamate receptors. It binds at an allosteric site on the GluR dimer interface, stabilizing the receptor's active conformation and reducing desensitization. This interaction facilitates prolonged excitatory synaptic signaling in vitro without directly activating the orthosteric glutamate site.

Indirect Effects on NMDA Receptor Currents

Experimental studies in cultured neurons suggest that IDRA–21 can indirectly influence NMDA

receptor–mediated currents, indicating a modulatory effect on excitatory synaptic signaling at

the cellular level.

Molecular Research Notes

Research studies describe IDRA-21 as an ampakine agent that can influence AMPA receptor-mediated synaptic transmission. Experimental models report modulation of synaptic activity, long-term potentiation (LTP), and receptor kinetics, providing an understanding of receptor-level mechanisms. IDRA-21 is studied strictly for laboratory research purposes and biochemical investigations.

Why Choose PureRawz for IDRA-21?

Buy IDRA-21 for laboratory research use from our online shop. At Purerawz, we provide high-quality reference materials. Each research compound comes with a Certificate of Analysis for verification of purity and concentration.

Note: IDRA 21 is an investigational compound currently undergoing clinical evaluation and has not been established as safe or effective for any therapeutic use

Disclaimer

This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By ordering, you agree to our Terms and Conditions. If you are not 100% satisfied with the product you received, please contact us at support@staging.purerawz.co

ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human use

Reference Links

PubChem. (n.d.-d). Idra 21. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/3688

Buccafusco, J. J., Weiser, T., Winter, K., Klinder, K., & Terry, A. V. (2003). The effects of IDRA 21, a positive modulator of the AMPA receptor, on delayed matching performance by young and aged rhesus monkeys. Neuropharmacology, 46(1), 10–22. https://doi.org/10.1016/j.neuropharm.2003.07.002

Losi, G., Angelucci, L., & Moroni, F. (2004). Modulation of NMDA receptor-mediated currents in cultured neurons by the ampakine IDRA-21. Neuropharmacology, 46(1), 101–110. https://pubmed.ncbi.nlm.nih.gov/15111017

Ptak, C. P., Ahmed, A. H., & Oswald, R. E. (2009). Probing the Allosteric Modulator Binding Site of GluR2 with Thiazide Derivatives. Biochemistry, 48(36),8594–8602. https://doi.org/10.1021/bi901127s

Dr. Helma Wennemers

Dr. Helma Wennemers is a globally recognized chemist shaping modern peptide science and molecular design through highly original research in applied biosciences.

Her work explores how precise molecular architecture can be engineered to create new functional systems in chemistry and life sciences. Her contributions continue to redefine contemporary chemical research through creativity, depth, and structural innovation.

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