Sulbutiamine

Description

Sulbutiamine Overview

Sulbutiamine is a synthetic derivative of thiamine (vitamin B1) developed through structural modification of the parent vitamin. The compound consists of two modified thiamine molecules connected through a disulfide bridge, which increases lipophilicity compared with native thiamine. This structural feature facilitates membrane permeability. Researchers have suggested that the structural feature may enable the molecule to cross lipid barriers more efficiently than water-soluble thiamine derivatives in preclinical research models.

It is frequently examined as a biochemical tool for studying thiamine metabolism in preclinical research models. 

Preclinical studies have suggested that Sulbutiamine may also contribute to intracellular thiamine phosphate formation and neuronal energy pathways. Experimental work focuses on its ability to influence intracellular thiamine derivatives and enzymatic systems that depend on thiamine cofactors.

Note: The product is strictly for research purposes. All the analytical studies are conducted under a strict laboratory environment.

Chemical and Molecular Properties

Chemical Name	Sulbutiamine
CAS Number	3286-46-2
Molecular Formula	C32H46N8O6S2
Molecular Weight	702.89 g/mol
Structural Class	Thiamine disulfide derivative
Physical Appearance	White or off-white crystalline powder
Solubility	Soluble in ethanol; slightly soluble in water
Key Structural Feature	Two thiamine units connected by a disulfide bridge

Proposed Working Mechanism of Sulbutiamine

A few experimental studies regarding Sulbutiamine demonstrate increased lipophilicity relative to thiamine. It may facilitate passive diffusion through lipid bilayers in experimental models. This property allows the compound to cross cellular membranes and reach intracellular compartments where enzymatic conversion occurs in research models.

Following cellular entry, reductive cleavage of the disulfide bond may generate thiamine-related intermediates. 

These intermediates undergo further enzymatic processing that leads to the formation of phosphorylated thiamine derivatives. The derivatives include thiamine monophosphate (ThMP), thiamine diphosphate (ThDP), and thiamine triphosphate (ThTP).

Note: The product is strictly for research purposes. All the analytical studies are conducted under a strict laboratory environment.

Why Choose Purerawz for Sulbutiamine?

Buy Sulbutiamine for laboratory research use from our online shop. At Purerawz, we provide high-quality reference materials. Each research compound comes with a Certificate of Analysis for verification of purity and concentration.

Disclaimer

This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By ordering, you agree to our Terms and Conditions. If you are not 100% satisfied with the product you received, please contact us at support@staging.purerawz.co

Reference Links

Starling-Soares, B., Carrera-Bastos, P., & Bettendorff, L. (2020). Role of the synthetic B1 vitamin sulbutiamine on health. Journal of Nutrition and Metabolism, 2020, 1-9. https://doi.org/10.1155/2020/9349063

Farid, N. F., & Abdelwahab, N. S. (2016). Stability-Indicating HPTLC Method for studying stress degradation behavior of sulbutiamine HCL. Journal of Chromatographic Science, 54(4), 609-617. https://doi.org/10.1093/chromsci/bmv226

Nagae, M., Parniske, M., Kawaguchi, M., & Takeda, N. (2016). The relationship between thiamine and two symbioses: Root nodule symbiosis and arbuscular mycorrhiza. Plant Signaling & Behavior, 11(12), e1265723. https://doi.org/10.1080/15592324.2016.1265723