Emoxypine Succinate

Description

Overview of Emoxypine Succinate

Emoxypine Succinate (2–ethyl–6–methyl–3–hydroxypyridine succinate) is a synthetic compound investigated in experimental and preclinical research for its biochemical and cellular properties. Structurally, it is derived from a 3–hydroxypyridine core and a succinate moiety, which together form a stable salt investigated for mechanisms including redox modulation, membrane interactions, and metabolic signaling in laboratory systems. Emoxypine Succinate is classified as an investigational research compound and is supplied exclusively for research use in controlled experimental settings. 

Chemical and Molecular Properties.

Emoxypine Succinate
PubChem CID	122298
Molecular Formula	C12H17NO5
Molecular Weight	255.27 g/mol
Synonyms	127464-43-1 mexidol methylethylpiridinol succinate 2R985002CT
IUPAC	butanedioic acid;2-ethyl-6-methylpyridin-3-ol
CAS	127464-43-1
Labeling	Research Use Only (RUO), not for human or animal consumption.
Chemical Structure Depiction
Purity	≥98%
Classification	Investigational research compound
Storage Temperature	Store lyophilized at −20 °C, protected from moisture and light
Solubility	Soluble in water and research‑grade solvents (e.g., DMSO) once reconstituted
Safety	Handle with gloves, a lab coat, eye protection; use a fume hood if dust/aerosol is possible

Various Mechanisms of Emoxypine Succinate

Antioxidant Activity in Experimental Systems

Emoxypine Succinate exhibits direct antioxidant activity characterized by free radical neutralization and modulation of oxidative stress markers. A mechanistic evaluation showed that the chemical activates endogenous redox pathways by inactivating free radicals and increasing glutathione peroxidase and superoxide dismutase activity in experimental systems under oxidative challenge. Additionally, increased expression of the transcription factor Nrf2 under ischemic conditions has been associated with enhanced cellular resistance to oxidative stress.

Mitochondrial Metabolic Modulation

Preclinical research on succinate-containing derivatives like Emoxypine Succinate suggests involvement in mitochondrial bioenergetic pathways. In isolated tissue models, oxidation of the succinate component within the mitochondrial respiratory chain was highlighted as a compensatory mechanism under limited oxygen availability, supporting cellular resistance to hypoxic stress via enhanced succinate oxidase pathway activity.

Membrane Interaction and Metabolic Signaling

Emoxypine Succinate interacts with cellular membranes, impacting lipid peroxidation rates and stability of phospholipid structures in laboratory models of ischemia-induced damage. Such interactions are studied to understand how structural perturbations affect membrane behavior and related signaling processes. 

Research Applications of Emoxypine Succinate

Emoxypine Succinate is utilized in experimental and preclinical research to investigate a range of mechanistic phenomena, including but not limited to:

• Oxidative Stress and Antioxidant Defense Pathways
• Hypoxia–Related Metabolic Pathways
• Gene Expression and Transcriptional Regulation

Why Choose Purerawz for Emoxypine Succinate?

Buy Emoxypine Succinate for laboratory research use from our online shop. At Purerawz, we provide high-quality reference materials. Each research compound comes with a Certificate of Analysis for verification of purity and concentration.

Note:

Emoxypine Succinate is an investigational compound currently undergoing clinical evaluation and has not been established as safe or effective for any therapeutic use

Disclaimer

This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By ordering, you agree to our Terms and Conditions. If you are not 100% satisfied with the product you received, please contact us at support@staging.purerawz.co

ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human use

Reference Links

Shchulkin AV. A modern concept of antihypoxic and antioxidant effects of mexidol. Zh Nevrol Psikhiatr Im S S Korsakova. 2018;118(12):87–93. https://pubmed.ncbi.nlm.nih.gov/30830123/

Luk’ianova LD, Atabaeva RE, Shepeleva SIu. Bioenergetic mechanisms of the antihypoxic action of mexidol, the succinate‑containing derivative of 3–hydroxypyridine. Biull Eksp Biol Med. 1993;115(3):259‑60. https://pubmed.ncbi.nlm.nih.gov/8054612/

Terekhina OL, Kirova YI. Effect of ethylmethylhydroxypyridine succinate on expression of PGC–1α, GR, SUCNR1, and SDHA genes in the cerebral cortex of old rats during dexamethasone administration. Bull Exp Biol Med. 2025;179(1):58–63. https://pubmed.ncbi.nlm.nih.gov/40679525/

Emoxypine Succinate—Compound Summary. PubChem Compound Database. National Center for Biotechnology Information. CID 122298. https://pubchem.ncbi.nlm.nih.gov/compound/122298

Mechanism overview of emoxypine succinate antioxidant and membrane protective pathways. Scientific Reports on pharmacological properties of Emoxypine Succinate. (Study compilation) https://www.sciencedirect.com/science/article/pii/S2590257122000414