SLU-PP-332

Description

SLU-PP-332 

Product Overview

SLU-PP-332 is a synthetic small-molecule compound that has been studied as an agonist of the estrogen-related receptor (ERR) family, including ERRα, ERRβ, and ERRγ. 

Estrogen-related receptors (ERRs) belong to the nuclear receptor superfamily and are involved in regulating genes associated with mitochondrial function and cellular metabolism.

Because ERR receptors play an important role in metabolic regulation, compounds such as SLU-PP-332 are being investigated to better understand mitochondrial biogenesis, metabolic adaptation, and energy utilization pathways.

Research on SLU-PP-332 remains preclinical, and the compound from PureRawz is primarily used for research purposes

Property	Description
Compound Name	SLU-PP-332
Molecular Formula	C18H14N2O2
Molecular Weight	290.3 g/mol
Synonyms	SLU-PP-332 303760-60-3 4-Hydroxy-N'-(naphthalen-2-ylmethylene)benzohydrazide CHEMBL4208749 (E)-4-Hydroxy-N'-(naphthalen-2-ylmethylene)benzohydrazide
UIPAC	4-hydroxy-N-[(E)-naphthalen-2-ylmethylideneamino]benzamide

Research Applications

Researchers have investigated whether SLU-PP-332 can influence mitochondrial gene expression and cellular respiration pathways in experimental models.

Preclinical studies have examined ERR activation in relation to metabolic conditions involving lipid accumulation, glucose metabolism, and insulin signaling pathways. 

Some investigations explore whether activation of ERR-related metabolic pathways may mimic certain molecular responses associated with endurance exercise in laboratory systems.

Mechanism of Action 

SLU-PP-332 is believed to interact with estrogen-related receptors, which regulate transcription of genes associated with mitochondrial function and oxidative metabolism.

Activation of ERR signaling pathways may influence mitochondrial gene expression, fatty acid oxidation pathways, and cellular energy utilization mechanisms

For this reason, SLU-PP-332 should only be handled by trained professionals within controlled laboratory environments.

Why Source Compounds from PureRawz

PureRawz supplies SLU-PP-332 as a research-grade compound for laboratory analysis and experimental investigation. They have features that include: Third-party laboratory testing and COA documentation available for each batch. These standards help ensure consistency for scientific studies examining steroid hormone pathways.

Research Disclaimer

This information is provided for educational and research reference purposes only.

All PureRawz products are supplied strictly for laboratory and scientific research use and are not intended for human or veterinary consumption.

Research must follow appropriate regulatory standards, including IRB or IACUC oversight where applicable.

References 

Casaburi, I., Avena, P., De Luca, A., et al. (2018). Estrogen related receptor alpha (ERRα): A potential target for metabolic disease research. International Journal of Molecular Sciences, 19(9), 2531. https://doi.org/10.3390/ijms19092531

Giguère, V. (2008). Transcriptional control of energy homeostasis by the estrogen-related receptors. Endocrine Reviews, 29(6), 677 696. https://doi.org/10.1210/er.2008-0017

Villena, J. A., & Kralli, A. (2008). ERRα: A metabolic function for the oldest orphan receptor. Trends in Endocrinology & Metabolism, 19(8), 269 276. https://doi.org/10.1016/j.tem.2008.07.001

Billon, C., & Auwerx, J. (2013). Estrogen-related receptors in metabolic control. Physiological Reviews, 93(2), 367 389. https://doi.org/10.1152/physrev.00007.2012