ISRIB

Description

ISRIB Powder Overview

ISRIB (Integrated Stress Response Inhibitor) is a synthetic small-molecule compound. It is investigated in biochemical and molecular biology research. The compound is studied for its interaction with the cellular regulatory network known as the Integrated Stress Response.

In laboratory environments, ISRIB is utilized as a research tool to examine how cells regulate protein synthesis and adapt to intracellular stress signals. Researchers frequently evaluate this compound in experimental systems to study translational control mechanisms and cellular signaling responses associated with stress adaptation.

In research models, ISRIB is commonly employed to explore:

• translational regulation of protein synthesis
• cellular signaling during stress response, and
• molecular mechanisms governing recovery of protein translation (in in vitro assays and preclinical models)

ISRIB powder formulations are supplied strictly as research materials intended for analytical and laboratory investigation.

ISRIB Powder

Property	Description
Compound Name	ISRIB
Class	Integrated Stress Response inhibitor
Molecular Formula	C22H24Cl2N2O4
Molecular Weight	451.34 g/mol
Research Category	Cellular stress response signaling research compound
Structural Class	Synthetic small-molecule translational regulator
Formulation	Research-grade powder

Mechanism of Action

Translational Control in Cellular Stress Response

ISRIB is studied in laboratory studies for its interaction with regulatory components of the Integrated Stress Response signaling network. This pathway regulates cellular protein translation during conditions that alter cellular homeostasis.

Modulation of Protein Synthesis Machinery

Experimental investigations examine ISRIB for its potential interaction with the translation initiation machinery associated with the eIF2 signaling axis. In biochemical assays, researchers study how ISRIB affects the recovery of protein synthesis under experimentally induced stress.

Regulation of Cellular Signaling Dynamics

In molecular research systems, ISRIB is analyzed for its ability to influence regulatory processes governing translational activity and intracellular signaling coordination. These mechanisms are frequently evaluated in studies investigating translational control and cellular stress adaptation pathways.

Research Applications

In controlled laboratory settings, ISRIB may be utilized for investigations involving:

• integrated stress response signaling assays
• translational control and protein synthesis regulation studies
• cellular stress signaling pathway analysis
• molecular investigations involving translation initiation complexes
• structure-function studies of translational regulatory compounds

All applications are strictly confined to experimental and analytical research environments.

Why Choose Purerawz?

Buy ISRIB powder for laboratory research use from our online shop. At Purerawz, we provide high-quality reference materials. Each compound is supplied with an independent third-party Certificate of Analysis verifying identity, purity, and analytical specifications.

Note: ISRIB (C22H24Cl2N2O4) is an investigational compound currently undergoing scientific evaluation and has not been established as safe or effective for any therapeutic application.

Disclaimer

This information is for educational purposes only and does not constitute medical advice.

THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the Institutional Animal Care and Use Committee (IACUC) in accordance with the guidelines of the Animal Welfare Act (AWA).

Our content is intended to be used for informational purposes only. It is important to conduct independent analysis and review research from trusted sources before making any purchase decision.

By completing and paying for your order, you agree to our Terms and Conditions. Customer satisfaction is our priority. If you are not fully satisfied with the product you received, please contact support@staging.purerawz.co/

ATTENTION: All products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human use.

References

Sidrauski C, Tsai JC, Kampmann M, et al. Pharmacological brake-release of mRNA translation enhances cognitive memory Science
https://pubmed.ncbi.nlm.nih.gov/26315442/

Sidrauski C, McGeachy AM, Ingolia NT, Walter P. The small molecule ISRIB reverses the effects of eIF2a phosphorylation on translation and stress granule assembly eLife
https://pubmed.ncbi.nlm.nih.gov/25031141//