Ibutamoren (MK-677)

Description

Overview of MK-677 (Ibutamoren)

MK-677, also known as Ibutamoren, is a compound being studied for its ability to mimic ghrelin, a hormone that triggers growth hormone (GH) release. Although it’s not FDA-approved for medical use, (R) it’s being tested in labs to see if it can increase GH levels.

Chemical and Molecular Properties 

MK-677
PubChem CID	178024
Molecular Formula	C27H36N4O5S
Synonyms	butamoren 159634-47-6 ibutamoreno
Molecular Weight	528.7 g/mol
IUPAC	2-amino-2-methyl-N-[(2R)-1-(1-methylsulfonylspiro[2H-indole-3,4'-piperidine]-1'-yl)-1-oxo-3-phenylmethoxypropan-2-yl]propanamide
Chemical Structure Depiction
CAS	159634-47-6
Hazards	Comprehensive hazard classification under GHS has not been fully established. Handle using standard laboratory safety precautions.
Classification	Research Use Only (RUO)
Storage Temperature
Solubility	DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): 10 mg/ml

How MK-677 Works

MK-677 is a small molecule that functions as an agonist of the ghrelin receptor (GHSR-1a). Activation of this receptor stimulates the release of growth hormone (GH) from the hypothalamus and pituitary gland. The increase in GH levels subsequently elevates insulin-like growth factor 1 (IGF-1), a protein involved in regulating cellular processes such as protein metabolism, tissue growth, and structural maintenance of bone.

Research Applications of MK-677

In research models, this pathway is studied for its effects on:

• Protein metabolism: IGF-1 promotes protein synthesis and turnover in tissues.
• Tissue growth: GH and IGF-1 signaling influence cell proliferation and differentiation in muscle-like and other tissues.
• Structural tissue density: The pathway can affect bone-forming cell activity and extracellular matrix composition.
• Energy storage and utilization: GH and IGF-1 can modulate lipid mobilization and distribution in tissues.

MK-677 acts as a non-peptide ghrelin mimetic, meaning it can trigger the ghrelin receptor without being a peptide hormone itself, making it useful for studying GH/IGF-1 axis regulation in various model systems.

Why Choose PureRawz for MK-677?

Buy MK-677 for laboratory research use from our online shop. At Purerawz, we provide high-quality reference materials. Each research compound comes with a Certificate of Analysis for verification of purity and concentration.

Note:

MK-677 is an investigational compound currently undergoing clinical evaluation and has not been established as safe or effective for any therapeutic use.

Disclaimer

This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By ordering, you agree to our Terms and Conditions. If you are not 100% satisfied with the product you received, please contact us at support@staging.purerawz.co

ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human use.

Reference Links

• PubChem. (n.d.-c). Ibutamoren mesylate (MK‑677) (CID 6450830). PubChem Compound Database. U.S. National Library of Medicine.  https://pubchem.ncbi.nlm.nih.gov/compound/6450830
• Costantino, L., & Barlocco, D. (2009). Ghrelin receptor modulators and their therapeutic  potential. Future Medicinal Chemistry, 1(1), 157‑177. https://doi.org/10.4155/fmc.09.9
• Cardaci, T. D., Machek, S. B., Wilburn, D. T., Heileson, J. L., Harris, D. R., Cintineo, H.  P., & Willoughby, D. S. (2022). LGD‑4033 and MK‑677 use impacts body composition, circulating biomarkers, and skeletal muscle androgenic hormone and receptor content:  A case report. Experimental Physiology, 107(12), 1467–1476. https://doi.org/10.1113/ep090741