YK-11 (Myostine)

Description

Overview of YK-11

YK-11 is a synthetic steroidal compound classified as a selective androgen receptor modulator (SARM). It is under investigation for its molecular interactions with androgen receptors and myostatin-related pathways. YK-11 is strictly for research use and is not approved for human or animal consumption.

Chemical and Molecular Properties

YK-11
PubChem CID	119058028
Molecular Formula	C25H34O6
Molecular Weight	430.5 g/mol
Synonyms	YK-11 Z9748J6B0R UNII-Z9748J6B0R
IUPAC	(17β)-17-hydroxy-17-methylandrost-1,4-dien-3-one furan CAS: 431579-34-9
CAS	431579-34-9
Labeling	Research Use Only (RUO), not for human or animal consumption.
Chemical Structure Depiction
Purity	≥98%
Classification	Research Use Only (RUO)
Storage Temperature	Lyophilized: –20 °C or colder
Solubility	DMSO, ethanol (research-grade solvents)
Safety	Handle with gloves, a lab coat, eye protection; use a fume hood if dust/aerosol is possible

YK‑11 Mechanism of Action

Androgen Receptor Interaction
YK‑11 binds to the androgen receptor (AR) and acts as a partial agonist, activating AR-mediated transcriptional signaling without promoting the full N‑terminal/C‑terminal (N/C) receptor interaction seen with potent endogenous agonists like dihydrotestosterone (DHT). This unique mode of receptor engagement appears to alter the conformational dynamics of AR and results in gene-selective transcriptional outcomes in cellular systems.

Regulation of Myogenesis & Follistatin Expression
In myoblast cell models (C2C12), YK‑11 stimulates the expression of myogenic regulatory factors (MRFs) such as MyoD, Myf5, and myogenin more significantly than DHT. It also uniquely induces follistatin (Fst) expression, a regulatory protein that antagonizes myostatin signaling—a pathway that normally suppresses muscle growth. Blocking Fst reverses the differentiation effects of YK‑11 in these cells, indicating Fst upregulation as a key component of its molecular effect.

Non‑Genomic Signaling and Osteoblastic Activity
Independent of classical genomic AR signaling, YK‑11 can activate non‑genomic pathways such as Akt signaling in osteoblastic cells. This activation has been associated with increased cell proliferation and bone‑specific differentiation markers (e.g., osteoprotegerin, osteocalcin), suggesting roles in skeletal cell biology that extend beyond traditional androgen receptor transcription. 

Why Choose PureRawz for YK-11 (Myostine)?

Buy YK-11 for laboratory research use from our online shop. At Purerawz, we provide high-quality reference materials. Each research compound comes with a Certificate of Analysis for verification of purity and concentration.

Note:

YK-11 is an investigational compound currently undergoing clinical evaluation and has not been established as safe or effective for any therapeutic use

Disclaimer

This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By ordering, you agree to our Terms and Conditions. If you are not 100% satisfied with the product you received, please contact us at support@staging.purerawz.co

ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human use

Reference Links

PubChem. (n.d.). YK-11 (CID 119058028). PubChem Compound Database. U.S. National Library of Medicine. https://pubchem.ncbi.nlm.nih.gov/compound/119058028 

Kanno Y, Hikosaka R, Zhang S‑Y, et al. (2011). (17α,20E)‑YK11 is a partial agonist of the androgen receptor. Biological & Pharmaceutical Bulletin, 34(3), 318‑323. https://pubmed.ncbi.nlm.nih.gov/21372378/

Kanno Y, Ota R, Someya K, Kusakabe T, et al. (2013). Selective androgen receptor modulator, YK11, regulates myogenic differentiation of C2C12 myoblasts by follistatin expression. Biological & Pharmaceutical Bulletin, 36(9), 1460‑1465. https://pubmed.ncbi.nlm.nih.gov/23995658/

Yatsu T, Kusakabe T, Kato K, Inouye Y, et al. (2018). Selective androgen receptor modulator, YK11, up–regulates osteoblastic proliferation and differentiation in MC3T3–E1 cells. Biological & Pharmaceutical Bulletin, 41(3), 394–398. https://pubmed.ncbi.nlm.nih.gov/29491216/