HBT1

Description

Overview of HBT1

HBT1 is a synthetic small-molecule compound under investigation as a research chemical. Researchers investigate its impact on glutamatergic receptor systems in conjunction with other substances. 

The compound is chemically defined and characterized by its distinct molecular structure, which includes a pyrazole and benzothiophene core. HBT1 is supplied exclusively for research purposes and has not been approved for human or animal use. Its well-defined chemical identity and purity make it suitable for in vitro and preclinical investigations into receptor pharmacology and signaling pathways.

Chemical and Molecular Properties 

HBT1
PubChem CID	1222102
Molecular Formula	C16H17F3N4O2S
Molecular Weight	386.4 g/mol
Synonyms	RefChem: 908944
IUPAC	2-[[2-[5-methyl-3-(trifluoromethyl)pyrazol-1-yl]acetyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS	489408-02-8
Labeling	Research Use Only (RUO), not for human or animal consumption.
Chemical Structure Depiction
Purity	≥98%
Classification	Research Use Only (RUO)
Storage Temperature	Store at −20 °C in a dry, light-protected environment
Solubility	DMSO and other research-grade organic solvents
Safety	Handle with gloves, a lab coat, eye protection; use a fume hood if dust/aerosol is possible

HBT1 Working Mechanism

AMPA Receptor Positive Allosteric Modulation

HBT1 mediates fast excitatory neurotransmission by acting as a positive allosteric modulator (PAM) of AMPA receptors, which are ionotropic glutamate receptors. In the receptor's ligand-binding domain (LBD), the chemical attaches to an allosteric site instead of the active glutamate-binding site.

Glutamate-mediated signaling is improved in experimental models by this binding, which stabilizes receptor conformations that promote channel opening in the presence of endogenous glutamate.

Glutamate-Dependent Receptor Potentiation

In in vitro electrophysiology studies, HBT1 demonstrates glutamate-dependent potentiation, meaning that receptor activity is enhanced only during ligand binding. This property reduces intrinsic agonistic activity while still promoting receptor signaling, allowing for the study of ion channel conductance and calcium influx in cellular models.

Modulation of Neurotrophic Signaling Pathways

HBT1's potentiation of AMPA receptors can affect intracellular signaling cascades linked to the expression of brain-derived neurotrophic factor (BDNF). The effects of allosteric modulation on intracellular calcium signaling and downstream transcriptional pathways have been investigated in studies employing neuronal cells. HBT1’s low intrinsic agonistic activity has been investigated as a tool for mechanistic research into receptor-mediated synaptic signaling without producing overstimulation artifacts observed with some other AMPA modulators.

Why Choose Purerawz for HBT1?

Buy HBT1 for laboratory research use from our online shop. At Purerawz, we provide high-quality reference materials. Each research compound comes with a Certificate of Analysis for verification of purity and concentration.

Note:

HBT1 is an investigational compound currently undergoing clinical evaluation and has not been established as safe or effective for any therapeutic use

Research Applications of HBT1 

HBT1 is used exclusively as a research tool in preclinical and experimental models. Its primary applications include:

• AMPA Receptor Pharmacology – Studying allosteric modulation in binding assays and electrophysiology.
• Synaptic Signaling and Plasticity – Investigating excitatory neurotransmission and long-term potentiation pathways.
• Neurotrophic Signaling—Examining BDNF-related transcriptional pathways and calcium-dependent intracellular signaling.
• Molecular Pharmacology—Serving as a reference compound for characterizing next-generation AMPA receptor modulators.

Disclaimer

This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By ordering, you agree to our Terms and Conditions. If you are not 100% satisfied with the product you received, please contact us at support@staging.purerawz.co

ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human use

Reference Links

Kunugi, A., Tajima, Y., Kuno, H., Sogabe, S., & Kimura, H. (2018). HBT1, a novel AMPA receptor potentiator with lower agonistic effect, avoided bell-shaped response in in vitro BDNF production. Journal of Pharmacology and Experimental Therapeutics, 364(3), 377–389. https://pubmed.ncbi.nlm.nih.gov/29298820/

PubChem Compound Summary for HBT1. National Center for Biotechnology Information, U.S. National Library of Medicine. https://pubchem.ncbi.nlm.nih.gov