Galantamine Hydrobromide

Description

Overview of Galantamine Hydrobromide

Galantamine Hydrobromide is a quaternary ammonium salt derived from galantamine, an alkaloid originally isolated from plants in the Amaryllidaceae family, including Galanthus (snowdrop) species. While the compound was first identified in botanical sources, galantamine used in modern laboratory studies is commonly produced through synthetic methods.

It is important to note that Purerawz only offers Galantamine Hydrobromide as a research chemical intended solely for laboratory use.

Chemical and Molecular Properties 

Galantamine Hydrobromide
PubChem CID	121587
Molecular Formula	C17H22BrNO3
Molecular Weight	368.3 g/mol
Synonyms	Nivaline Nivalin
IUPAC	(1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetracyclo[8.6.1.01,12.06,17]heptadeca-6(17),7,9,15-tetraen-14-ol;hydrobromide
CAS	1953-04-4
Labeling	Research Use Only (RUO), not for human or animal consumption.
Chemical Structure Depiction
Purity	≥98%
Classification	Acetylcholinesterase inhibitor (research compound)
Storage Temperature	Lyophilized at −20 °C; reconstituted solutions at 2–8°C
Solubility	Soluble in water and DMSO
Safety	Handle with gloves, a lab coat, eye protection; use a fume hood if dust/aerosol is possible

Various Mechanisms of Galantamine Hydrobromide

Acetylcholinesterase Inhibition 

Galantamine hydrobromide acts as a reversible competitive inhibitor of acetylcholinesterase in experimental systems. Acetylcholinesterase is responsible for hydrolyzing the neurotransmitter acetylcholine within cholinergic synapses.

By inhibiting this enzyme in laboratory models, galantamine allows acetylcholine to persist longer in the synaptic cleft, enabling researchers to investigate the effects of elevated cholinergic signaling in neuronal systems.

Allosteric Modulation of Nicotinic Acetylcholine Receptors

In addition to acetylcholinesterase inhibition, galantamine has been reported to function as a positive allosteric modulator of nicotinic acetylcholine receptors (nAChRs) in experimental models.

Rather than binding to the primary ligand site, the compound interacts with alternative receptor domains that influence receptor conformation. This mechanism can enhance receptor responsiveness to acetylcholine, making galantamine a useful compound for studying receptor-mediated cholinergic signaling pathways in vitro.

Research Applications of Galantamine Hydrobromide

Galantamine hydrobromide is widely used in experimental neuroscience and biochemical research to investigate cholinergic signaling pathways. Common laboratory research applications include:

• Cholinergic neurotransmission studies
• Acetylcholinesterase inhibition assays
• Nicotinic receptor modulation research
• Neurotransmitter signaling pathway investigations
• Preclinical models examining cholinergic system dynamics

Why Choose Purerawz for Galantamine Hydrobromide?

Buy Galantamine Hydrobromide for laboratory research use from our online shop. At Purerawz, we provide high-quality reference materials. Each research compound comes with a Certificate of Analysis for verification of purity and concentration.

Note:

Galantamine Hydrobromide is an investigational compound currently undergoing clinical evaluation and has not been established as safe or effective for any therapeutic use

Disclaimer

This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By ordering, you agree to our Terms and Conditions. If you are not 100% satisfied with the product you received, please contact us at support@staging.purerawz.co

ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human use

Reference Links

Maelicke A., Albuquerque E.X. Allosteric potentiating ligands of nicotinic receptors as a treatment strategy for Alzheimer's disease. European Journal of Pharmacology. https://pubmed.ncbi.nlm.nih.gov/10942046/

Scott L.J., Goa K.L. Galantamine: a review of its use in Alzheimer's disease. Drugs.  https://pubmed.ncbi.nlm.nih.gov/11129124/

Heinrich M., Teoh H.L. Galanthamine from snowdrop – the development of a modern drug against Alzheimers disease from local Caucasian knowledge. Journal of Ethnopharmacology. https://pubmed.ncbi.nlm.nih.gov/15137996/

PubChem Compound Summary – Galantamine Hydrobromide. https://pubchem.ncbi.nlm.nih.gov/compound/121587