Nicotinamide Mononucleotide (NMN)

Description

Nicotinamide Mononucleotide (NMN) Overview

Nicotinamide mononucleotide (NMN) is a nucleotide-derived compound that functions as a biochemical precursor to nicotinamide adenine dinucleotide (NAD+), a coenzyme involved in numerous cellular processes. NAD+ is present in virtually all living cells and participates in a wide range of metabolic and enzymatic reactions.

In laboratory research environments, NMN is investigated for its role in cellular metabolism, energy regulation, and NAD+ biosynthesis pathways. Due to its biochemical properties, NMN has become a subject of interest in studies exploring cellular signaling and metabolic regulation.

Chemical and Molecular Properties

PubChem CID	14180
Molecular Formula	C11H15N2O8P
Molecular Weight	334.22 g/mol
Synonyms	Nicotinamide ribotide 2KG6QX4W0V Pyridinium, 3-(aminocarbonyl)-1-(5-O-phosphono-beta-D-ribofuranosyl)-, inner salt DTXSID50911152
IUPAC	[(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate
CAS	1094-61-7
Labeling	Research Use Only (RUO), not for human or animal consumption.
Chemical Structure Depiction
Purity	99% Purity
Classification	Research Use Only (RUO)
Storage Temperature	Store at controlled room temperature, typically between 15°C to 30°C (59°F to 86°F)

Mechanisms of Action

NMN is primarily studied for its ability to contribute to intracellular NAD+ biosynthesis.

NAD+ plays an essential role in numerous metabolic reactions, including those involving:

• Cellular energy production
• DNA repair processes
• Enzyme activation
• Cellular stress responses

By serving as a precursor molecule, NMN is investigated for how it influences NAD+ -dependent biochemical pathways in experimental models.

Potential Research Applications

Current scientific interest in nicotinamide mononucleotide (NMN) primarily centers on its role in cellular metabolism and NAD+ biosynthesis. The following areas summarize topics that have been explored in laboratory research.

• Cellular Energy Metabolism

NMN is frequently investigated for its involvement in metabolic pathways that regulate intracellular NAD+ production.

• Sirtuin and Enzyme Signaling Pathways

Laboratory studies often examine NMN in connection with NAD+ -dependent enzymes, including members of the sirtuin family.

• Cellular Stress and DNA Maintenance Mechanisms

NMN is also explored in studies focused on cellular responses to oxidative stress and DNA maintenance pathways.

• Metabolic Regulation Studies

In experimental animal models, researchers investigate how NMN influences metabolic signaling pathways, including those associated with energy balance and nutrient metabolism.

• Neurobiological Research

Certain preclinical studies explore NMN within the context of neuronal metabolism and cellular signaling in neural tissues.

• Cardiovascular and Vascular Biology Research

NMN has also been examined in laboratory models that study endothelial cell function, oxidative stress pathways, and vascular signaling mechanisms.

Disclaimer

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References:

1. Gujar, A. D., Le, S., Mao, D. D., Dadey, D. Y. A., Turski, A., Sasaki, Y., Aum, D., Luo, J., Dahiya, S., Yuan, L., Rich, K. M., Milbrandt, J., Hallahan, D. E., Yano, H., Tran, D. D., & Kim, A. H. (2016). An NAD+ -dependent transcriptional program governs self-renewal and radiation resistance in glioblastoma. Proceedings of the National Academy of Sciences, 113(51), E8247–E8256. https://doi.org/10.1073/pnas.1610921114
2. Song, J., Li, J., Yang, F., Ning, G., Zhen, L., Wu, L., Zheng, Y., Zhang, Q., Lin, D., Xie, C., & Peng, L. (2019). Nicotinamide mononucleotide promotes osteogenesis and reduces adipogenesis by regulating mesenchymal stromal cells via the SIRT1 pathway in aged bone marrow. Cell Death and Disease, 10(5), 336. https://doi.org/10.1038/s41419-019-1569-2
3. Mills, K. F., Yoshida, S., Stein, L. R., Grozio, A., Kubota, S., Sasaki, Y., Redpath, P., Migaud, M. E., Apte, R. S., Uchida, K., Yoshino, J., & Imai, S. (2016). Long-Term administration of nicotinamide mononucleotide mitigates Age-Associated physiological decline in mice. Cell Metabolism, 24(6), 795–806. https://doi.org/10.1016/j.cmet.2016.09.013