Nefiracetam

Description

Nefiracetam Overview

Nefiracetam is a fat-soluble nootropic compound belonging to the racetam family. Like other racetams, it contains a pyrrolidone nucleus, which gives the compound its distinct chemical properties.

As a cholinergic research compound, Nefiracetam has been studied in laboratory models for its potential effects on acetylcholine activity. The latter is a neurotransmitter associated with learning, focus, and memory formation. Preclinical studies indicate that Nefiracetam may also influence memory-related pathways and neuronal protection in controlled research settings.

Chemical and Molecular Properties

PubChem CID	71157
Molecular Formula	C14H18N2O2
Molecular Weight	246.30 g/mol
Synonyms	77191-36-7 Nefiracetamum DM-9384 1-Pyrrolidineacetamide, N-(2,6-dimethylphenyl)-2-oxo-
IUPAC	N-(2,6-dimethylphenyl)-2-(2-oxopyrrolidin-1-yl)acetamide
CAS	77191-36-7
Labeling	Research Use Only (RUO), not for human or animal consumption.
Chemical Structure Depiction
Purity	99% Purity
Classification	Research Use Only (RUO)
Storage Temperature	Store at controlled room temperature, 20°C to 25°C (68°F to 77°F)

Mechanisms of Action

In laboratory and animal studies, Nefiracetam is believed to act through several pathways:

• Enhancing neuronal signaling: May modulate calcium channels in neurons, supporting communication between brain cells.
• Supporting neurotransmitters: Observed to influence acetylcholine activity, a key mediator of learning and memory in research models.
• Promoting brain plasticity: Preclinical studies suggest potential effects on pathways related to BDNF (Brain-Derived Neurotrophic Factor) and NGF (Nerve Growth Factor).
• Neuroprotection: Laboratory models indicate Nefiracetam may reduce cell death and support neuronal resilience following injury or chemical stress.

Potential Research Applications

Nefiracetam has been investigated for its effects in multiple preclinical models:

Memory and Cognition

• Studied for potential improvements in learning and memory using laboratory models.
• Research indicates effects on acetylcholine and glutamate signaling, which are critical for information storage and recall.
• Demonstrated reversal of experimentally induced memory deficits in animal studies using substances such as ethanol, scopolamine, and anesthetics.

Neuroprotection

• Observed to preserve vital proteins like BDNF and synapsin I in ischemia and brain injury models.
• Suggests potential use in laboratory research on neuronal resilience and recovery mechanisms.

Mood and Emotional Regulation

• Certain animal studies indicate possible anxiolytic (calming) and antidepressant-like effects.
• Appears to influence GABAergic and cholinergic pathways in research models, potentially balancing relaxation and alertness in preclinical studies.

Brain Plasticity and Growth

• Shown to support neuritogenesis, the growth of new connections between neurons.
• Laboratory studies demonstrate potential enhancement of neurotrophic factors such as BDNF and NGF, critical for neuron survival, growth, and function.

Disclaimer

This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By ordering, you agree to our Terms and Conditions. If you are not 100% satisfied with the product you received, please contact us at support@staging.purerawz.co

ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human use

References:

1. Nomura, T., & Nishizaki, T. (2000). Nefiracetam facilitates hippocampal neurotransmission by a mechanism independent of the piracetam and aniracetam action. Brain Research, 870(1-2), 157-162.https://doi.org/10.1016/s0006-8993(00)02417-3
2. Aihara, H., Li, X., Fujiwara, S., Matsumura, T., Okumura, S., Tozaki, H., Kanno, T., Ohta, K., Nagai, K., & Nishizaki, T. (2001). The protective action of nefiracetam against electrophysiological and metabolic damage in the hippocampus after deprivation of glucose and oxygen. Brain Research, 922(1), 158-162. https://doi.org/10.1016/s0006-8993(01)03165-1
3. Fujita, R., Takayama, N., & Ueda, H. (2002). The cognition-enhancer nefiracetam is protective in BDNF-independent neuronal cell death under the serum-free condition. Neurochemistry International, 40(2), 139-143. https://doi.org/10.1016/s0197-0186(01)00080-8