Bromantane

Description

Bromantane

Bromantane is a synthetic compound structurally derived from the adamantane chemical framework, a class of cage-like hydrocarbons frequently investigated in pharmacological research due to their unique physicochemical stability and lipophilic properties.

The compound was first synthesized in the late 20th century and has since been referenced in scientific literature in connection with actoprotective and neurochemical signaling research.

Within experimental and preclinical contexts, Bromantane has been examined for its interactions with dopaminergic signaling systems and intracellular regulatory pathways. Early investigations, particularly those originating from Russian pharmacological research programs, explored the compound's potential role in modulating cellular responses to metabolic and environmental stressors within controlled laboratory models.

Chemical and Molecular Properties

Chemical Name	Bromantane
IUPAC Name	N-(4-bromophenyl)adamantan-2-amine
CAS Number	87913-26-6
Molecular Formula	C16H20BrN
Molecular Weight	306.25 g/mol
Chemical Classification	Adamantane derivative
Structural Class	Substituted amine
Synonyms	Ladasten; N-(4-bromophenyl)-2-adamantanamine
Labeling	Research Use Only (RUO)

Working Mechanism

Dopamine Biosynthesis Pathway Modulation

Experimental pharmacology research has investigated Bromantane for its influence on dopamine biosynthesis pathways at the molecular level. Preclinical studies indicate that the compound may increase the expression of key enzymes involved in dopamine synthesis, including:

• Tyrosine hydroxylase (TH)
  
• Aromatic L-amino acid decarboxylase (AAAD)

These enzymes are responsible for catalyzing critical steps in the biochemical conversion of tyrosine to dopamine within neuronal systems. In experimental models, increased expression of these enzymes may alter the capacity for dopamine biosynthesis within dopaminergic neurons.

This mechanism differs from compounds that primarily influence neurotransmitter release or transporter inhibition, as Bromantane has been studied for its potential effects on enzyme regulation and neurotransmitter production pathways.

Intracellular Signaling Pathway Activation

Research conducted in cell culture and animal models has also explored Bromantane's effects on intracellular signaling networks associated with gene expression and enzymatic regulation.

Experimental observations suggest the compound may interact with signaling pathways involving:

• cyclic adenosine monophosphate (cAMP)
  
• calcium-dependent signaling systems (Ca2+)
  
• protein kinase signaling cascades

Activation of these pathways in laboratory models has been associated with transcriptional regulation of genes involved in catecholamine synthesis, potentially influencing the expression of dopamine-related biosynthetic enzymes.

These signaling interactions are typically examined through biochemical assays, molecular pathway analysis, and gene expression studies in experimental research systems.

Neurochemical Regulation in Experimental Systems

Because Bromantane influences enzyme expression rather than direct neurotransmitter release, it has been investigated as a compound that may modulate dopaminergic tone through biosynthetic regulation.

Preclinical research has examined how this mechanism affects dopamine-related signaling networks within neuronal research models. Investigations frequently utilize molecular biology techniques to measure enzyme expression levels, signaling pathway activation, and intracellular regulatory responses.

Research Applications of Bromantane in Laboratory Settings

Dopamine Biosynthesis Research

Experimental models may evaluate how Bromantane influences the expression of enzymes involved in dopamine synthesis, including tyrosine hydroxylase and aromatic L-amino acid decarboxylase.

Neurotransmitter Signaling Studies

Cell-based assays and biochemical experiments may analyze the compound's interactions with dopaminergic signaling pathways and neurotransmitter biosynthesis regulation.

Intracellular Signaling Pathway Investigation

In vitro experimental systems may investigate Bromantane's potential effects on signaling networks such as cAMP-dependent pathways, calcium signaling, and protein kinase activation.

Stress Response Research in Experimental Models

Preclinical investigations have examined Bromantane in studies analyzing cellular responses to metabolic and environmental stress conditions, including research involving immune signaling pathways and toxin resistance in animal models.

Structure-Activity Relationship (SAR) Studies

Because Bromantane belongs to the adamantane structural class, it may be included in research examining structure-activity relationships among adamantane derivatives and related amine compounds.

These studies aim to characterize molecular interactions, enzyme regulation, and signaling responses under controlled laboratory conditions.

Why Choose Purerawz for Bromantane?

Buy Bromantane for laboratory research use from our online shop. At Purerawz, we provide high-quality reference materials. Each research compound comes with a Certificate of Analysis for verification of purity and concentration.

Disclaimer

This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By ordering, you agree to our Terms and Conditions. If you are not 100% satisfied with the product you received, please contact us at support@staging.purerawz.co

Reference Links

• Grekhova, T. V., Gainetdinov, R. R., Sotnikova, T. D., Krasnykh, L. M., Kudrin, V. S., Sergeeva, S. A., & Morozov, I. S. (1995). Effect of bromantane, a new immunostimulating agent with psychostimulating activity, on the release and metabolism of dopamine in the striatum of freely moving rats. A microdialysis study. Bulletin of Experimental Biology and Medicine, 119(3), 294-296. https://doi.org/10.1007/bf02445840
• Morozov, I. S., Klimova, N. V., Karpova, T. D., & Shestopalov, S. S. (1999). [The characteristics of the neuropsychotropic activity of bromantane in laboratory animals]. PubMed, 62(2), 3-6. https://pubmed.ncbi.nlm.nih.gov/10340117