Laxogenin (5a-Hydroxy Laxogenin)

Description

Laxogenin (5a-Hydroxy Laxogenin) Overview

Laxogenin is a plant-based steroid derived from brassinosteroids, a group of plant hormones known to regulate growth and protein metabolism in plant cells. In cell-based studies, certain brassinosteroids have been shown to increase protein synthesis while reducing protein breakdown, which has led to laxogenin being referred to as a "plant anabolic" in research contexts.

Laboratory studies suggest that specific brassinosteroid compounds may stimulate protein production in muscle cells, supporting research into lean tissue growth and intracellular signaling pathways.

Chemical and Molecular Properties

PubChem CID	10950057
Molecular Formula	C27H42O4
Molecular Weight	430.6 g/mol
Synonyms	1177-71-5 6-Oxotigogenin HT7W184YG4 (1R,2S,4S,5'R,6R,7S,8R,9S,12S,13R,16S,18S)-16-hydroxy-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icosane-6,2'-oxane]-19-one
IUPAC	(1R,2S,4S,5'R,6R,7S,8R,9S,12S,13R,16S,18S)-16-hydroxy-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icosane-6,2'-oxane]-19-one
CAS	1177-71-5
Labeling	Research Use Only (RUO), not for human or animal consumption.
Chemical Structure Depiction
Purity	99% Purity
Classification	Research Use Only (RUO)
Storage Temperature	Store at controlled room temperature, 20°C to 25°C (68°F to 77°F)

Mechanisms of Action

Plant steroids such as laxogenin operate via mechanisms distinct from human anabolic hormones. Research indicates that laxogenin:

• Activates cell surface signaling pathways that influence protein production.
• Engages AKT1 (protein kinase B), a protein linked to the regulation of protein synthesis and reduced muscle protein breakdown in cellular and animal models.
• Inhibits phosphodiesterase, the enzyme responsible for breaking down cAMP, leading to increased intracellular cAMP levels and activation of downstream signaling pathways associated with metabolic activity.

These mechanisms are currently observed in cell and animal models only.

Potential Research Applications

Laxogenin is used in laboratory settings to study:

• Protein synthesis and degradation pathways - Investigates how plant steroids influence muscle protein production and breakdown in cells.
• Intracellular signaling mechanisms in muscle cells - Explores how laxogenin activates pathways like AKT1 and cAMP-mediated signaling.
• Cellular responses to plant-derived steroid compounds - Examines how muscle and other cell types react to brassinosteroid exposure.
• Metabolic processes, including cAMP-mediated signaling - Studies the effects on energy regulation and fat metabolism at the cellular level.

Disclaimer

This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By ordering, you agree to our Terms and Conditions. If you are not 100% satisfied with the product you received, please contact us at support@staging.purerawz.co

ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human use

References:

1. Nikaido, T., Ohmoto, T., Kubo, S., Mimaki, Y., & Sashida, Y. (1992). Steroidal saponins from the rhizomes of Smilax sieboldii. Phytochemistry, 31(7), 2445-2450. https://doi.org/10.1016/0031-9422(92)83296-b
2. Baba, M., Masayoshi, Kishi, N., Okada, Y., Shibata, S., Peng, J., Yao, S., Nishino, H., & Okuyama, T. (2000). Saponins Isolated from Allium chinense G. DON and Antitumor-promoting Activities of Isoliquiritigenin and Laxogenin from the Same Drug. Biological and Pharmaceutical Bulletin, 23(5), 660-662. https://doi.org/10.1248/bpb.23.660
3. Esposito, D., Kizelsztein, P., Komarnytsky, S., & Raskin, I. (2012). Hypoglycemic effects of brassinosteroid in diet-induced obese mice. American Journal of Physiology-Endocrinology and Metabolism, 303(5), E652-E658. https://doi.org/10.1152/ajpendo.00024.2012