DMHA

Description

DMHA Overview

DMHA, also known as dimethylhexylamine, is a synthetic aliphatic amine that has been investigated in laboratory settings for its stimulant-like properties and interactions with central nervous system signaling pathways.

This compound is commonly referred to by several alternative names, including:

• 2-Amino-6-methylheptane
• 2-Methyl-5-aminoheptane
• Octodrine
• Amridine
• Vaporpac

In experimental models, DMHA has been explored for its potential influence on dopaminergic and noradrenergic signaling pathways, which are involved in neurological and physiological regulation.

Chemical and Molecular Properties

PubChem CID	10982
Molecular Formula	C8H19N
Molecular Weight	129.24 g/mol
Synonyms	1,5-Dimethylhexylamine 2-Amino-6-methylheptane 6-Methyl-2-heptylamine Amidrine
IUPAC	6-methylheptan-2-amine
CAS	543-82-8
Labeling	Research Use Only (RUO), not for human or animal consumption
Chemical Structure Depiction
Purity	99% Purity
Classification	Research Use Only (RUO), not for human or animal consumption
Storage Temperature	Store at temperature 2°C and 8°C (36°F to 46°F)
Solubility	Water, DMSO (research-grade solvents)
Safety	Handle with gloves, a lab coat, eye protection; use a fume hood if dust/aerosol is possible

Mechanisms of Action

Laboratory investigations suggest that DMHA may influence neurotransmitter signaling pathways, particularly those involving dopamine and norepinephrine (noradrenaline).

These neurotransmitters are associated with several biological processes studied in neuroscience research, including:

• Neurochemical signaling pathways
• Neuromodulation and synaptic activity
• Stress-response signaling networks

Experimental work suggests that DMHA may interact with mechanisms related to sympathomimetic activity, although its precise biochemical pathways remain under investigation.

Potential Research Applications

DMHA has been explored in laboratory settings for its interactions with neurological and physiological signaling pathways. Experimental studies have investigated its potential influence on dopaminergic and noradrenergic activity, which are associated with central nervous system signaling.

Researchers have also examined DMHA in structure–activity relationship (SAR) studies due to its structural similarities to other sympathomimetic amines. These investigations may help characterize how related compounds interact with receptor systems and intracellular signaling pathways.

In addition, some experimental models have evaluated DMHA in relation to cardiovascular and respiratory parameters in preclinical research. Laboratory studies have also explored its activity in microbial assays, including investigations involving E. coli in controlled in-vitro environments.

Current information on DMHA primarily comes from preclinical and laboratory-based research, and further investigation is required to better understand its properties.

Disclaimer

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References:

1. The pharmacology of 2-amino-6-methylheptane. (1947, August 1). PubMed. https://pubmed.ncbi.nlm.nih.gov/20265812
2. [Comparison of the bronchodilatory action in man of three aliphatic amines in aerosol]. (1950, April 15). PubMed. https://pubmed.ncbi.nlm.nih.gov/15414026/
3. Professional, C. C. M. (2025, November 14). Norepinephrine (Noradrenaline). Cleveland Clinic. https://my.clevelandclinic.org/health/articles/22610-norepinephrine-noradrenaline