N-Acetyl Semax Amidate

Description

N-Acetyl Semax Amidate - Overview

N-Acetyl Semax Amidate, also known as N-Acetyl Semax, is a synthetic peptide that is derived from the naturally occurring neuropeptide called ACTH (Adrenocorticotropic hormone). It is a modified version of the original Semax peptide, created by adding an Acetyl group and an Amidate group to enhance its stability and bioavailability.

N-Acetyl Semax Amidate is primarily researched for its potential cognitive and neuroprotective effects. It is believed to interact with various neurotransmitter systems in the brain, including dopamine, serotonin, and norepinephrine. This may contribute to its effects on neuronal signaling and cognitive-related pathways in research models.

Chemical Properties

Property	Information
CAS Number	2920938-90-3
Molecular Formula	C39H54N10O10S
Molecular Mass	855.0 g/mol
Synonyms	N-acetyl semax, N-acetyl semax amidate, HY-P3588, EX-A13574
IUPAC Name	(4S)-4-[[(2S)-2-acetamido-4-methylsulfanylbutanoyl]amino]-5-[[(2S)-1-[[(2S)-1-[(2S)-2-[[2-[(2S)-2-carbamoylpyrrolidin-1-yl]-2-oxoethyl]carbamoyl]pyrrolidin-1-yl]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
Storage	2-8°C (36-46°F)

Mechanism of Action of N-Acetyl Semax Amidate

N-Acetyl Semax Amidate is considered a modified form of the Semax peptide. However, its exact molecular mechanism is still being investigated in research settings. Studies suggest that Semax-related peptides may cross the blood–brain barrier in experimental models. They may also interact with several signaling systems in the brain, including serotonin, dopamine, and enkephalin pathways. These neurotransmitter systems are studied for their roles in cognitive signaling, stress responses, and reward-related processes.

Research also suggests that Semax-derived peptides may affect neurotrophic factors such as brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF). These factors are involved in neuronal growth and cellular signaling pathways. However, these mechanisms remain under investigation and continue to be explored in controlled laboratory models.

Research Findings on N-Acetyl Semax

Experimental studies have investigated how Semax influences gene expression in brain tissue. Research reported that Semax altered the expression of several genes involved in neurotransmission, immune signaling, and neuronal plasticity. These findings suggest that Semax-derived peptides may participate in regulatory pathways associated with cellular signaling and neurotrophic processes in research environments.

Another study examined the effect of Semax on neurotrophic factors associated with neuronal survival and plasticity. Researchers observed increased expression of brain-derived neurotrophic factor (BDNF) and related signaling receptors in experimental models. These results indicate that Semax-related peptides may influence pathways linked to neuronal growth and cellular communication.

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Reference Links

PubChem. (2026). N-acetyl semax amidate. Nih.gov; PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/172638603

Medvedeva, E. V., Dmitrieva, V. G., Povarova, O. V., Limborska, S. A., Skvortsova, V. I., Myasoedov, N. F., & Dergunova, L. V. (2014). The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis. BMC Genomics, 15(1), 228. https://doi.org/10.1186/1471-2164-15-228

Agapova, T. I., Agniullin, I. V., Silachev, D. N., Shadrina, M. I. Slominskii, P. A., Shram, S. I., Limborskaia, S. A., & Miasoedov, N. F. (2008). Effect of semax on the temporary dynamics of brain-derived neurotrophic factor and nerve growth factor gene expression in the rat hippocampus and frontal cortex. Molekuliarnaia Genetika, Mikrobiologiia I Virusologiia, 3, 28-32. https://pubmed.ncbi.nlm.nih.gov/18756821/